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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621405
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hey2
Name: hes-related family bHLH transcription factor with YRPW motif 2
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hey2multiple interactionsEXP 6480464CTDNiclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]PMID:28318631
Hey2increases expressionISOHEY2 (Homo sapiens)6480464CTDNiclosamide results in increased expression of HEY2 mRNAPMID:19160421
Hey2multiple interactionsISOHEY2 (Homo sapiens)6480464CTDN-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]PMID:19160421
Hey2multiple interactionsISOHey2 (Mus musculus)6480464CTDNiclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY2 mRNA]PMID:28318631
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