GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1i3 | increases activity | EXP | | 6480464 | CTD | Meclizine results in increased activity of NR1I3 protein alternative form; Meclizine results in increased activity of NR1I3 protein mutant form | PMID:21778469 | Nr1i3 | increases activity | ISO | NR1I3 (Homo sapiens) | 6480464 | CTD | Meclizine results in increased activity of NR1I3 protein alternative form | PMID:21778469 | Nr1i3 | increases activity | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | Meclizine results in increased activity of NR1I3 protein alternative form; Meclizine results in increased activity of NR1I3 protein mutant form | PMID:21778469 | Nr1i3 | multiple interactions | ISO | NR1I3 (Homo sapiens) | 6480464 | CTD | Meclizine binds to and results in decreased activity of NR1I3 protein; Meclizine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein]; Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA]; Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP2B10 mRNA]; Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP3A11 mRNA]; Meclizine inhibits the reaction [NR1I3 protein binds to NCOA1 protein] | PMID:15272053 | Nr1i3 | multiple interactions | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of ABCC2 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP2B10 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP3A11 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of GSTA1 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of UGT1A1 mRNA; Meclizine binds to and results in increased activity of NR1I3 protein; Meclizine promotes the reaction [NR1I3 protein binds to NCOA1 protein] | PMID:15272053 | |
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