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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311104
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nceh1
Name: neutral cholesterol ester hydrolase 1
Acc ID: CHEBI:59849
Term: ecothiopate iodide
Definition: The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.
Chemical ID: MESH:D004456
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nceh1decreases activityISONceh1 (Mus musculus)6480464CTDEchothiophate Iodide results in decreased activity of NCEH1 proteinPMID:16978018
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