RGD ID: 11275
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl2
Name: chemokine (C-C motif) ligand 2
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Definition Source(s): Beilstein:2049713, CAS:15687-27-1, CAS:15687-27-1, CAS:15687-27-1, Drug_Central:1407, DrugBank:DB01050, HMDB:HMDB0001925, KEGG:C01588, KEGG:D00126, LINCS:LSM-1354, Patent:GB971700, Patent:US3228831, Patent:US3385886, Patent:US5215755, Patent:US6727286, PMID:11433218, PMID:12723739, PMID:14562167, PMID:15506544, PMID:16176022, PMID:18335846, PMID:18697608, PMID:21368281, PMID:24168233, PMID:25708941, PMID:25915907, Reaxys:2049713, Wikipedia:Ibuprofen
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDIbuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]

Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]

increases expressionISORGD:7310466480464CTDIbuprofen results in increased expression of CCL2 mRNA

multiple interactionsISORGD:7310466480464CTDIbuprofen inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]

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