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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fzd1
Name: frizzled class receptor 1
Acc ID: CHEBI:4887
Term: ethosuximide
Definition: A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Chemical ID: MESH:D005013
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fzd1increases expressionEXP 6480464CTDEthosuximide results in increased expression of FZD1 mRNAPMID:26420483
Fzd1multiple interactionsEXP 6480464CTDEthosuximide inhibits the reaction [APP protein modified form results in decreased expression of FZD1 mRNA]PMID:26420483
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