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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:4887
Term: ethosuximide
Definition: A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Chemical ID: MESH:D005013
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appmultiple interactionsEXP 6480464CTDEthosuximide inhibits the reaction [APP protein modified form results in decreased expression of APC mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of AXIN1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CCND1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CTNNB1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of DCX mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of FZD1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LEF1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LRP6 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NES mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NEUROD1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of PAX6 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of STAT3 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT3 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of DKK1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of GSK3B mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of WIF1 mRNA]PMID:26420483
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