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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dkk1
Name: dickkopf WNT signaling pathway inhibitor 1
Acc ID: CHEBI:4887
Term: ethosuximide
Definition: A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Chemical ID: MESH:D005013
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dkk1decreases expressionEXP 6480464CTDEthosuximide results in decreased expression of DKK1 mRNAPMID:26420483
Dkk1multiple interactionsEXP 6480464CTDEthosuximide inhibits the reaction [APP protein modified form results in increased expression of DKK1 mRNA]PMID:26420483
Dkk1multiple interactionsISODKK1 (Homo sapiens)6480464CTDDKK1 protein inhibits the reaction [Ethosuximide results in decreased phosphorylation of CTNNB1 protein]; DKK1 protein inhibits the reaction [Ethosuximide results in increased phosphorylation of GSK3B protein]PMID:26420483
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