Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca8
Name: ATP binding cassette subfamily A member 8
Acc ID: CHEBI:4551
Term: digoxin
Definition: A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.
Chemical ID: MESH:D004077
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abca8multiple interactionsISOABCA8 (Homo sapiens)6480464CTDDigoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]PMID:12379217
Go Back to source page   Continue to Ontology report