RGD ID: 620218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Creb1
Name: cAMP responsive element binding protein 1
Acc ID: CHEBI:4495
Term: diazoxide
Definition: A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Definition Source(s): Beilstein:523907, CAS:364-98-7, Drug_Central:854, DrugBank:DB01119, HMDB:HMDB0015251, KEGG:C06949, KEGG:D00294, LINCS:LSM-3639, Patent:DE723278, Patent:US2986573, Patent:US3345365, PMID:11014217, PMID:12039709, PMID:15319354, PMID:16740260, PMID:16777075, PMID:18191077, PMID:20828743, PMID:20950601, PMID:21538163, PMID:21693179, PMID:22047130, Reaxys:523907, Wikipedia:Diazoxide
Chemical ID: MESH:D003981
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
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