Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3157
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nedd4
Name: NEDD4 E3 ubiquitin protein ligase
Acc ID: CHEBI:4450
Term: desmopressin
Definition: A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.
Chemical ID: MESH:D003894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nedd4increases expressionEXP 6480464CTDDeamino Arginine Vasopressin results in increased expression of NEDD4 proteinPMID:21734099
Go Back to source page   Continue to Ontology report