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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Avpr2
Name: arginine vasopressin receptor 2
Acc ID: CHEBI:4450
Term: desmopressin
Definition: A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.
Chemical ID: MESH:D003894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Avpr2multiple interactionsEXP 6480464CTD[Deamino Arginine Vasopressin binds to and results in increased activity of AVPR2 protein] which results in decreased activity of 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidPMID:1399968
Avpr2multiple interactionsISOAVPR2 (Homo sapiens)6480464CTDDeamino Arginine Vasopressin binds to and results in increased activity of AVPR2 proteinPMID:15685210
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