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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2142
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aqp2
Name: aquaporin 2
Acc ID: CHEBI:4450
Term: desmopressin
Definition: A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.
Chemical ID: MESH:D003894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp2increases expressionEXP 6480464CTDDeamino Arginine Vasopressin results in increased expression of AQP2 proteinPMID:16675087
Aqp2multiple interactionsEXP 6480464CTDDeamino Arginine Vasopressin inhibits the reaction [aluminum lactate results in decreased expression of AQP2 protein]; Deamino Arginine Vasopressin results in increased expression of and results in increased uptake of and results in increased ubiquitination of AQP2 proteinPMID:16675087 PMID:21734099
Aqp2increases expressionISOAqp2 (Mus musculus)6480464CTDDeamino Arginine Vasopressin results in increased expression of AQP2 mRNA; Deamino Arginine Vasopressin results in increased expression of AQP2 proteinPMID:16495377
Aqp2multiple interactionsISOAqp2 (Mus musculus)6480464CTDLithium inhibits the reaction [Deamino Arginine Vasopressin results in increased expression of AQP2 mRNA]; Lithium inhibits the reaction [Deamino Arginine Vasopressin results in increased expression of AQP2 protein]PMID:16495377
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