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REFERENCE - CHEMICAL INTERACTIONS REPORT

RGD ID: 21201308
Species: All species
RGD Object: Reference
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1decreases expression IEP 21201308RGDMethotrexate decreases Nqo1 mRNA in the liver 
NQO1decreases expression ISONqo1 (Rattus norvegicus)21201308RGDMethotrexate decreases Nqo1 mRNA in the liver 
Nqo1decreases expression ISONqo1 (Rattus norvegicus)21201308RGDMethotrexate decreases Nqo1 mRNA in the liver 
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