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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1decreases expression ISONqo1 (Rattus norvegicus)21201308RGDMethotrexate decreases Nqo1 mRNA in the liver 
Nqo1decreases response to substanceEXP 6480464CTDNQO1 mRNA results in decreased susceptibility to MethotrexatePMID:16918715
Nqo1decreases expressionISONqo1 (Rattus norvegicus)6480464CTDMethotrexate results in decreased expression of NQO1 mRNAPMID:15120968
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