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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308225
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gtf2h1
Name: general transcription factor IIH subunit 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gtf2h1affects expressionISOGTF2H1 (Homo sapiens)6480464CTDValproic Acid affects the expression of GTF2H1 mRNAPMID:25979313
Gtf2h1affects expressionISOGtf2h1 (Mus musculus)6480464CTDValproic Acid affects the expression of GTF2H1 mRNAPMID:17292431
Gtf2h1decreases methylationISOGTF2H1 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of GTF2H1 genePMID:29154799
Gtf2h1increases expressionISOGTF2H1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of GTF2H1 mRNAPMID:23179753
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