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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732257
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTP1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTP1affects bindingISOGstp1 (Rattus norvegicus)1641942RGD1-chloro-2,4-dinitrobenzene binds to Gstp1 protein  
GSTP1affects metabolic processingEXP 6480464CTDGSTP1 protein affects the metabolism of Dinitrochlorobenzene; GSTP2 protein affects the metabolism of DinitrochlorobenzenePMID:10870112 PMID:15355982 PMID:3570286
GSTP1decreases response to substanceEXP 6480464CTDGSTP1 protein mutant form results in decreased susceptibility to DinitrochlorobenzenePMID:37031912
GSTP1increases activityEXP 6480464CTDDinitrochlorobenzene results in increased activity of GSTP1 protein mutant formPMID:37031912
GSTP1multiple interactionsEXP 6480464CTDGSTP1 protein SNP binds to and results in increased glutathionylation of Dinitrochlorobenzene; Mercuric Chloride inhibits the reaction [GSTP1 protein SNP binds to and results in increased glutathionylation of Dinitrochlorobenzene]; methylmercuric chloride inhibits the reaction [GSTP1 protein SNP binds to and results in increased glutathionylation of Dinitrochlorobenzene]; Sodium Selenite inhibits the reaction [GSTP1 protein SNP binds to and results in increased glutathionylation of Dinitrochlorobenzene]PMID:22401947
GSTP1affects metabolic processingISOGstp1 (Rattus norvegicus)6480464CTDGSTP1 protein affects the metabolism of DinitrochlorobenzenePMID:2619714
GSTP1decreases activityISOGstp1 (Rattus norvegicus)6480464CTDDinitrochlorobenzene results in decreased activity of GSTP1 proteinPMID:9794801
GSTP1increases expressionISOGstp1 (Rattus norvegicus)6480464CTDDinitrochlorobenzene results in increased expression of GSTP1 proteinPMID:9794801
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