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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstp1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstp1affects bindingEXP 1641942RGD1-chloro-2,4-dinitrobenzene binds to Gstp1 protein  
Gstp1affects metabolic processingEXP 6480464CTDGSTP1 protein affects the metabolism of DinitrochlorobenzenePMID:2619714
Gstp1decreases activityEXP 6480464CTDDinitrochlorobenzene results in decreased activity of GSTP1 proteinPMID:9794801
Gstp1increases expressionEXP 6480464CTDDinitrochlorobenzene results in increased expression of GSTP1 proteinPMID:9794801
Gstp1affects metabolic processingISOGSTP1 (Homo sapiens)6480464CTDGSTP1 protein affects the metabolism of Dinitrochlorobenzene; GSTP2 protein affects the metabolism of DinitrochlorobenzenePMID:10870112 PMID:15355982 PMID:3570286
Gstp1decreases response to substanceISOGSTP1 (Homo sapiens)6480464CTDGSTP1 protein mutant form results in decreased susceptibility to DinitrochlorobenzenePMID:37031912
Gstp1increases activityISOGSTP1 (Homo sapiens)6480464CTDDinitrochlorobenzene results in increased activity of GSTP1 protein mutant formPMID:37031912
Gstp1multiple interactionsISOGSTP1 (Homo sapiens)6480464CTDGSTP1 protein SNP binds to and results in increased glutathionylation of Dinitrochlorobenzene; Mercuric Chloride inhibits the reaction [GSTP1 protein SNP binds to and results in increased glutathionylation of Dinitrochlorobenzene]; methylmercuric chloride inhibits the reaction [GSTP1 protein SNP binds to and results in increased glutathionylation of Dinitrochlorobenzene]; Sodium Selenite inhibits the reaction [GSTP1 protein SNP binds to and results in increased glutathionylation of Dinitrochlorobenzene]PMID:22401947
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