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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1563216
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Isca2
Name: iron-sulfur cluster assembly 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Isca2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ISCA2 mRNAPMID:34947998
Isca2increases expressionEXP 6480464CTDbisphenol A results in increased expression of ISCA2 mRNAPMID:25181051 PMID:30816183 PMID:32528016
Isca2increases methylationEXP 6480464CTDbisphenol A results in increased methylation of ISCA2 genePMID:28505145
Isca2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ISCA2 promoter; [bisphenol A co-treated with Testosterone] results in increased expression of ISCA2 mRNAPMID:23359474 PMID:26496021
Isca2decreases expressionISOIsca2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of ISCA2 mRNAPMID:33221593
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