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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315200
Species: Mus musculus
RGD Object: Gene
Symbol: Krt34
Name: keratin 34
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krt34decreases expressionISOKrt34 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of KRT34 mRNAPMID:25181051
Krt34increases methylationISOKrt34 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of KRT34 genePMID:28505145
Krt34multiple interactionsISOKrt34 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Genistein] results in increased methylation of KRT34 genePMID:28505145
Krt34multiple interactionsISOKRT34 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KRT34 mRNA; [Phenolsulfonphthalein deficiency co-treated with bisphenol A] results in increased expression of KRT34 proteinPMID:28628672 PMID:31629898
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