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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308225
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gtf2h1
Name: general transcription factor IIH subunit 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gtf2h1increases expressionEXP 6480464CTDbisphenol A results in increased expression of GTF2H1 mRNAPMID:25181051
Gtf2h1decreases expressionISOGTF2H1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of GTF2H1 proteinPMID:31675489
Gtf2h1increases methylationISOGTF2H1 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of GTF2H1 genePMID:31601247
Gtf2h1multiple interactionsISOGTF2H1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of GTF2H1 genePMID:31601247
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