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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314464
Species: Mus musculus
RGD Object: Gene
Symbol: Dennd6a
Name: DENN domain containing 6A
Acc ID: CHEBI:31653
Term: glafenine
Definition: A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.
Chemical ID: MESH:D005897
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dennd6adecreases expressionISODennd6a (Rattus norvegicus)6480464CTDGlafenine results in decreased expression of DENND6A mRNAPMID:24136188
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