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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737557
Species: Mus musculus
RGD Object: Gene
Symbol: Thrb
Name: thyroid hormone receptor beta
Acc ID: CHEBI:3131
Term: bithionol
Definition: An aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, but withdrawn after being shown to be a potent photosensitizer with the potential to cause serious skin disorders.
Chemical ID: MESH:D001735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thrbincreases activityISOThrb (Rattus norvegicus)6480464CTDBithionol results in increased activity of THRB proteinPMID:22015988
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