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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61830
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnab3
Name: potassium voltage-gated channel subfamily A regulatory beta subunit 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnab3decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of KCNAB3 mRNAPMID:21839799
Kcnab3increases expressionISOKCNAB3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of KCNAB3 mRNAPMID:22316170
Kcnab3increases methylationISOKCNAB3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of KCNAB3 3' UTRPMID:27901495
Kcnab3multiple interactionsISOKcnab3 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to KCNAB3 promoter]PMID:19654925
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