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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1603301
Species: Homo sapiens
RGD Object: Gene
Symbol: DCHS2
Name: dachsous cadherin-related 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DCHS2affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of DCHS2 exon; Benzo(a)pyrene affects the methylation of DCHS2 intron; Benzo(a)pyrene affects the methylation of DCHS2 promoterPMID:27901495 PMID:30157460
DCHS2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of DCHS2 mRNAPMID:32234424
DCHS2increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of DCHS2 5' UTRPMID:27901495
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