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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561420
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il27
Name: interleukin 27
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il27multiple interactionsEXP 6480464CTD[IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in decreased expression of PPARG protein]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased activity of MPO protein]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP1 protein]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of HIF1A mRNA]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of IL17A mRNA]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of IL18 mRNA]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of NLRP3 protein]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of PYCARD protein]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of NFKBIA protein]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in increased activity of MPO protein]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL18 mRNA]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of NLRP3 protein]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of PYCARD protein]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]PMID:34999049
Il27decreases expressionISOIL27 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of IL27 mRNAPMID:32234424
Il27increases methylationISOIL27 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of IL27 promoterPMID:27901495
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