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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309305
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc39a12
Name: solute carrier family 39 member 12
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc39a12decreases methylationISOSLC39A12 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of SLC39A12 5' UTRPMID:27901495
Slc39a12increases methylationISOSLC39A12 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SLC39A12 promoterPMID:27901495
Slc39a12multiple interactionsISOSlc39a12 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to SLC39A12 promoter]PMID:19654925
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