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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:28952
Term: 5alpha-pregnane-3,20-dione
Definition: A C21-steroid hormone that is 5α-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone.
Chemical ID: MESH:D043582
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTD5-alpha-Dihydroprogesterone results in increased expression of BCL2 mRNAPMID:19931389
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD3-hydroxypregn-4-en-20-one inhibits the reaction [5-alpha-Dihydroprogesterone results in increased expression of BCL2 mRNA]PMID:19931389
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