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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305216
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt6
Name: sirtuin 6
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt6decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of SIRT6 proteinPMID:34713381
Sirt6multiple interactionsEXP 6480464CTDDoxorubicin inhibits the reaction [SIRT6 protein binds to FAS promoter]; Doxorubicin inhibits the reaction [SIRT6 protein binds to FASLG promoter]; Doxorubicin promotes the reaction [SIRT6 protein binds to TP53 protein]; SIRT6 protein inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to FAS promoter]]; SIRT6 protein inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to FASLG promoter]]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of GPX1 mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of HMGB1 protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of PRDX5 mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of SOD2 mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased acetylation of TP53 protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP8 protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FADD protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FASLG mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FASLG protein modified form]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of RIPK1 protein modified form]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of RIPK3 protein]PMID:34713381
Sirt6decreases expressionISOSirt6 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of SIRT6 proteinPMID:34713381
Sirt6increases response to substanceISOSirt6 (Mus musculus)6480464CTDSIRT6 gene mutant form results in increased susceptibility to DoxorubicinPMID:34713381
Sirt6multiple interactionsISOSirt6 (Mus musculus)6480464CTDSIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of CAT mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of CAT protein]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of FAS mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of FASL mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of GPX1 mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of PRDX5 mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of SOD2 mRNA]; SIRT6 protein promotes the reaction [Doxorubicin results in decreased expression of RIPK1 protein]PMID:34713381
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