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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:25879
Term: pentaerythritol tetranitrate
Definition: A pentaerythritol nitrate in which all four hydroxy groups of pentaerythritol have been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to those of glyceryl trinitrate, but with a more prolonged duration of action, and is used for treatment of angina pectoris. It is also one of the most powerful high explosives known and is a component of the plastic explosive known as Semtex.
Chemical ID: MESH:D010417
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases activityEXP 6480464CTDPentaerythritol Tetranitrate results in increased activity of HMOX1 proteinPMID:17541025
Hmox1increases expressionEXP 6480464CTDPentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA; Pentaerythritol Tetranitrate results in increased expression of HMOX1 proteinPMID:17541025
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDPentaerythritol Tetranitrate results in increased expression of HMOX1 mRNAPMID:17092343
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDPentaerythritol Tetranitrate results in increased expression of HMOX1 mRNAPMID:17641250
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