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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vasp
Name: vasodilator-stimulated phosphoprotein
Acc ID: CHEBI:25879
Term: pentaerythritol tetranitrate
Definition: A pentaerythritol nitrate in which all four hydroxy groups of pentaerythritol have been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to those of glyceryl trinitrate, but with a more prolonged duration of action, and is used for treatment of angina pectoris. It is also one of the most powerful high explosives known and is a component of the plastic explosive known as Semtex.
Chemical ID: MESH:D010417
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vaspincreases phosphorylationEXP 6480464CTDPentaerythritol Tetranitrate results in increased phosphorylation of VASP proteinPMID:15331769 PMID:17541025
Vaspmultiple interactionsEXP 6480464CTDBenomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein]PMID:15331769
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