GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a2 | decreases activity | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | erdafitinib results in decreased activity of CYP3A4 protein | PMID:34189909 | Cyp3a2 | increases metabolic processing | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein results in increased metabolism of erdafitinib | PMID:34189909 | Cyp3a2 | multiple interactions | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Rivaroxaban]; erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A4 protein]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]]; Testosterone inhibits the reaction [erdafitinib results in decreased activity of CYP3A4 protein] | PMID:34189909 | | ||||||||||||||||||||||
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