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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:231515
Term: lanthanum trichloride
Definition: The trichloride salt of lanthanum.
Chemical ID: MESH:C028521
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcdecreases expressionISOGclc (Mus musculus)6480464CTDlanthanum chloride results in decreased expression of GCLC proteinPMID:33098623
Gclcincreases expressionISOGclc (Mus musculus)6480464CTDlanthanum chloride results in increased expression of GCLC mRNA; lanthanum chloride results in increased expression of GCLC proteinPMID:24142884
Gclcmultiple interactionsISOGCLC (Homo sapiens)6480464CTD[cerous chloride co-treated with lanthanum chloride] results in increased expression of GCLC mRNAPMID:28954213
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