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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68335
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Por
Name: cytochrome p450 oxidoreductase
Acc ID: CHEBI:230671
Term: misonidazole
Definition: null
Chemical ID: MESH:D008920
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Porincreases metabolic processingEXP 6480464CTDPOR protein results in increased metabolism of MisonidazolePMID:6802140
Pormultiple interactionsEXP 6480464CTDdesmethylmisonidazole inhibits the reaction [POR protein results in increased metabolism of Misonidazole]; Flavins promotes the reaction [POR protein results in increased metabolism of Misonidazole]; Nitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]; Nitrofurazone inhibits the reaction [POR protein results in increased metabolism of Misonidazole]; Paraquat promotes the reaction [POR protein results in increased metabolism of Misonidazole]PMID:6802140
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