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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620873
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il23a
Name: interleukin 23 subunit alpha
Acc ID: CHEBI:230506
Term: apilimod
Definition: Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 in IFNg/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs. Apilimod is a potent and highly selective PIKfyve inhibitor.
Chemical ID: MESH:C504227
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il23adecreases expressionISOIL23A (Homo sapiens)6480464CTDapilimod results in decreased expression of IL23A mRNAPMID:21348542
Il23amultiple interactionsISOIL23A (Homo sapiens)6480464CTDapilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL23A protein binds to IL12B protein]]PMID:17053051
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