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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2854
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Iapp
Name: islet amyloid polypeptide
Acc ID: CHEBI:180693
Term: EUK-8
Definition: A manganese coordination entity in which manganese(III) is coordinated to a salen ligand and a chlorine atom. It is a superoxide dismutase and catalase mimetic.
Chemical ID: MESH:C090577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Iappdecreases metabolic processingISOIAPP (Homo sapiens)6480464CTDN,N'-bis(salicylideneamino)ethane-manganese(II) results in decreased metabolism of IAPP proteinPMID:23528352
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