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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621405
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hey2
Name: hes-related family bHLH transcription factor with YRPW motif 2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hey2decreases expressionISOHey2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of HEY2 mRNA; Diethylhexyl Phthalate results in decreased expression of HEY2 proteinPMID:29377175 PMID:31086358
Hey2multiple interactionsISOHey2 (Mus musculus)6480464CTDVerapamil promotes the reaction [Diethylhexyl Phthalate results in decreased expression of HEY2 mRNA]; Verapamil promotes the reaction [Diethylhexyl Phthalate results in decreased expression of HEY2 protein]; Verapamil promotes the reaction [Diethylhexyl Phthalate results in increased expression of HEY2 mRNA]PMID:31086358
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