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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1563858
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hesx1
Name: HESX homeobox 1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hesx1increases expressionISOHesx1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of HESX1 mRNAPMID:33484791
Hesx1multiple interactionsISOHesx1 (Mus musculus)6480464CTD[Diethylhexyl Phthalate co-treated with Streptozocin co-treated with Dietary Fats] results in decreased expression of HESX1 mRNA; Diethylhexyl Phthalate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of HESX1 mRNA]PMID:33484791
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