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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2370
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cntf
Name: ciliary neurotrophic factor
Acc ID: CHEBI:17045
Term: dinitrogen oxide
Definition: A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
Chemical ID: MESH:D009609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cntfdecreases activityISOCNTF (Homo sapiens)6480464CTDNitrous Oxide results in decreased activity of CNTF proteinPMID:15748169
Cntfmultiple interactionsISOCNTF (Homo sapiens)6480464CTDNitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Nitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]PMID:15748169
Cntfmultiple interactionsISOCntf (Mus musculus)6480464CTDNitrous Oxide inhibits the reaction [CNTF protein results in increased activity of STAT3 protein]PMID:15748169
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