Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1608327
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Mir146
Name:	microRNA 146

Acc ID:	CHEBI:16412
Term:	lipopolysaccharide
Definition:	Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID:	MESH:D008070

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Mir146	decreases expression	ISO	RGD:1344673	152177908	RGD	LPS decreases expression of MIR146A mRNA in chondrocytes from RA patients
Mir146	increases expression	EXP		6480464	CTD	Lipopolysaccharides results in increased expression of MIR146 mRNA	PMID:25890327
Mir146	increases expression	ISO	RGD:1344673	6480464	CTD	Lipopolysaccharides results in increased expression of MIR146A; Lipopolysaccharides results in increased expression of MIR146A mRNA	PMID:24863965 PMID:32392329 PMID:35781746
Mir146	multiple interactions	ISO	RGD:1344673	6480464	CTD	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased expression of MIR146A mRNA]; MIR146A mRNA affects the reaction [Lipopolysaccharides results in increased expression of CD74A protein]; MIR146A mRNA affects the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; MYD88 affects the reaction [Lipopolysaccharides results in increased expression of MIR146A mRNA]	PMID:24863965 PMID:35781746

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