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Pathways

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2854
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Iapp
Name: islet amyloid polypeptide
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Iappdecreases abundanceEXP 6480464CTDIAPP protein results in decreased abundance of Hydrogen PeroxidePMID:23793354
Iappincreases chemical synthesisEXP 6480464CTDIAPP protein results in increased chemical synthesis of Hydrogen PeroxidePMID:23793354
Iappmultiple interactionsEXP 6480464CTDCopper promotes the reaction [IAPP protein results in increased chemical synthesis of Hydrogen Peroxide]; IAPP protein promotes the reaction [[Copper co-treated with Ascorbic Acid] results in increased abundance of Hydrogen Peroxide]PMID:23793354
Iappdecreases abundanceISOIAPP (Homo sapiens)6480464CTDIAPP protein results in decreased abundance of Hydrogen PeroxidePMID:23793354
Iappincreases chemical synthesisISOIAPP (Homo sapiens)6480464CTDIAPP protein results in increased chemical synthesis of Hydrogen PeroxidePMID:23793354
Iappmultiple interactionsISOIAPP (Homo sapiens)6480464CTDCopper promotes the reaction [IAPP protein results in increased chemical synthesis of Hydrogen Peroxide]; IAPP protein inhibits the reaction [[Copper co-treated with Glutathione] results in increased abundance of Hydrogen Peroxide]PMID:23793354
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