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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61276
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crhr1
Name: corticotropin releasing hormone receptor 1
Acc ID: CHEBI:139557
Term: antalarmin
Definition: A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidin-4-amine which is substituted by methyl groups at positions 2, 5, and 6, by a mesityl group at position 7, and in which the amino substituent at position 4 has been substituted by ethyl and butyl groups. It is an antagonist of corticotropin-releasing factor 1 (CRF-1) receptors (Ki = 1 nM).
Chemical ID: MESH:C103016
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crhr1multiple interactionsISOCRHR1 (Homo sapiens)6480464CTDantalarmin binds to and results in decreased activity of CRHR1 proteinPMID:16014403
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