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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 12185421
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: ACHE
Name: acetylcholinesterase
Acc ID: CHEBI:136185
Term: VX nerve agent
Definition: A organic thiophosphate that is the ethyl ester of S-{2-[di(propan-2-yl)amino]ethyl} O hydrogen methylphosphonothioate. A toxic nerve agent used in chemical warfare.
Chemical ID: MESH:C009680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACHEdecreases activityEXP 6480464CTDVX results in decreased activity of ACHE proteinPMID:16915560
ACHEmultiple interactionsEXP 6480464CTD[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein]PMID:16915560
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