Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:132774
Term: roxadustat
Definition: An N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH).
Chemical ID: MESH:C584543
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1amultiple interactionsEXP 6480464CTDroxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]PMID:27082295
Hif1aincreases activityISOHIF1A (Homo sapiens)6480464CTDroxadustat results in increased activity of HIF1A proteinPMID:29741670
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]PMID:29741670
Go Back to source page   Continue to Ontology report