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GENE - TERM ANNOTATION REPORT

RGD ID: 9147096
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Frat1
Name: FRAT regulator of WNT signaling pathway 1
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Frat1involved_inISOFRAT1 (Homo sapiens)1624291RGDUniProtKB:O14640 UniProtKB:P49674 PMID:10428961 PMID:12556519

PMID:10428961 PMID:12556519
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