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GENE - TERM ANNOTATION REPORT

RGD ID: 8950512
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Akr1a1
Name: aldo-keto reductase family 1 member A1
Acc ID: PW:0001565
Term: doxorubicin pharmacokinetics pathway
Definition: The pathway of processing - absorption, distribution, metabolism or elimination - of doxorubicin. Doxorubicin is used as a chemotherapeutic agent for the treatment of various cancers. Its use is limited by the serious cardiotoxic side effects it exerts. Genetic variations can result in changes in the availability of the drug.
Definition Source(s): PMID:21048526
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1a1 ISOAKR1A1 (Homo sapiens)9068941RGD PMID:19442138 PMID:21048526 REF_RGD_ID:10395261 REF_RGD_ID:10395262
Akr1a1 ISOAKR1A1 (Homo sapiens)9068941SMPDB SMP:00650
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