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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735109
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Unc5c
Name: unc-5 netrin receptor C
Acc ID: CHEBI:85990
Term: panobinostat
Definition: A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.
Chemical ID: MESH:C496932
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Unc5caffects expressionISOUNC5C (Homo sapiens)6480464CTDpanobinostat affects the expression of UNC5C mRNAPMID:26733615
Unc5cincreases expressionISOUNC5C (Homo sapiens)6480464CTDpanobinostat results in increased expression of UNC5C mRNAPMID:26272509
Unc5cmultiple interactionsISOUNC5C (Homo sapiens)6480464CTD(+)-JQ1 compound promotes the reaction [Panobinostat affects the expression of UNC5C mRNA]; [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA; Panobinostat promotes the reaction [(+)-JQ1 compound affects the expression of UNC5C mRNA]PMID:26733615 PMID:27188386
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