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GENE - TERM ANNOTATION REPORT

RGD ID: 727850
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kiss1
Name: KiSS-1 metastasis-suppressor
Acc ID: GO:0007186
Term: G protein-coupled receptor signaling pathway
Definition: The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
Definition Source(s): GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kiss1acts_upstream_of_or_withinISOKiss1 (Mus musculus)1624291RGD MGI:2662348 PMID:12359743

MGI:2662348 PMID:12359743
Kiss1 TAS 1299570RGD  
Kiss1involved_inIBAMGI:2663985 or PANTHER:PTN002704209 or Kiss1 (Rattus norvegicus)1600115GO_CentralGO_REF:0000033

GO_REF:0000033
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