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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727850
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kiss1
Name: KiSS-1 metastasis-suppressor
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kiss1decreases expressionISOKiss1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in decreased expression of KISS1 mRNA; perfluorooctane sulfonic acid results in decreased expression of KISS1 proteinPMID:26358002 PMID:29939337
Kiss1multiple interactionsISOKiss1 (Mus musculus)6480464CTDEstrogens inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of KISS1 mRNA]; perfluorooctane sulfonic acid inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of KISS1 mRNA]; perfluorooctane sulfonic acid inhibits the reaction [Estradiol results in increased expression of KISS1 mRNA]; perfluorooctane sulfonic acid inhibits the reaction [Estradiol results in increased expression of KISS1 protein]PMID:26358002 PMID:29939337
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