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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708540
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl6
Name: C-X-C motif chemokine ligand 6
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl6increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of CXCL5 mRNAPMID:15212814 PMID:15834898
Cxcl6multiple interactionsISOCxcl5 (Mus musculus)6480464CTD[Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of CXCL5 mRNA]; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of CXCL5 mRNA]PMID:12072388
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