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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708540
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl6
Name: C-X-C motif chemokine ligand 6
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl6increases expressionISOCXCL6 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CXCL6 mRNAPMID:35811015
Cxcl6increases expressionISOCxcl5 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of CXCL5 mRNAPMID:21356202 PMID:22687549
Cxcl6increases secretionISOCxcl5 (Mus musculus)6480464CTDLipopolysaccharides results in increased secretion of CXCL5 proteinPMID:32800949
Cxcl6multiple interactionsISOCXCL6 (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CXCL6 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of CXCL6 mRNAPMID:35811015
Cxcl6multiple interactionsISOCxcl5 (Mus musculus)6480464CTD2'-hydroxyflavanone inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL5 protein]; genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL5 mRNA]PMID:22687549 PMID:32800949
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